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Gender differences in Nociceptin/ Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system.

机译：在对代谢综合征易发（WOKW）和耐药（Dark Agouti）的大鼠中，Nociceptin / Orphanin FQ诱导的食物摄入的性别差异：可卡因和苯丙胺调节的转录系统可能参与其中。

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Our previous study found that when injected\udwith Nociceptin/Orphanin FQ (N/OFQ) into the brain,\udmale Dark Agouti (DA) rats, which are resistant to metabolic\udsyndrome, have greater hyperphagia than male Wistar\udOttawa Karlsburg W(WOKW) animals, which are prone to\udthis disease. We attributed this difference to the fact that\udthese two strains have different cocaine-amphetamine\udregulated transcript peptide (Cart) gene sequences and\udexpression. In order to address this hypothesis, the present\udwork focused on sex differences and analyzed not only\udmale but also female N/OFQ-induced (0.25 and 0.5 nmol/\udrat) food intake in terms of their Cart and N/OFQ receptor\udgene expression in the hypothalamic area. In N/OFQ-naive\udWOKW females, cart gene expression is extremely elevated\udcompared to N/OFQ-naive WOKW males. When\udmale and female WOKW littermates are stimulated with\udN/OFQ, the food intake of females is significantly lower\udthan that of the males. Granted, the N/OFQ feeding\udbehavior experiments were not performed on the animals\udmeasured for Cart gene expression, but nonetheless, the\udresponses observed in littermates point to an interesting\udavenue for further inquiry.

机译：我们以前的研究发现，当向脑中注射\ nucceptin / orphanin FQ（N / OFQ）\ udud的暗黑豚鼠（DA）大鼠时，其对代谢\ udsyndrome的抵抗力比男性Wistar \ udOttawa Karlsburg W（ WOKW）容易患这种疾病的动物。我们将此差异归因于以下事实：\这两个菌株具有不同的可卡因-苯丙胺\转录肽（Cart）基因序列和表达异常。为了解决这个假设，本研究着眼于性别差异，不仅分析了男性，而且还分析了女性的N / OFQ诱导的食物摄入量（分别为Cart和N / OFQ受体）（0.25和0.5 nmol / udrat） \ udgene表达在下丘脑区域。在没有N / OFQ的WOKW雌性中，cart基因的表达与没有N / OFQ的WOKW雄性相比非常高。当用\ udN / OFQ刺激男性和女性WOKW同窝仔时，女性的食物摄入量显着低于男性。当然，未对未测量Cart基因表达的动物进行N / OFQ喂养/行为学实验，但尽管如此，在同窝幼仔中观察到的\反应表明仍是一个有趣的\进一步研究的途径。

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Battistoni S; Kloting I; Cifani C; Massi M; Polidori C;
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年度 2011
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1. Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system [J] . Serena Battistoni, Ingrid Kloting, Carlo Cifani, Genes and Nutrition . 2011,第2期

机译：易感（WOKW）和抗药性（Dark Agouti）大鼠新陈代谢综合症中的品系中，伤害感受肽/孤啡肽FQ诱导的食物摄入的性别差异：可卡因和苯丙胺调节的转录系统可能参与
2. Nociceptin/orphanin FQ-induced food intake and cocaine amphetamine regulated transcript gene expression in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome. [J] . Cifani C, Kloting I, Morini G, Peptides: An International Journal . 2009,第4期

机译：Nociceptin / orphanin FQ诱导的食物摄取和可卡因苯丙胺调节了易患代谢综合征（WOKW）和耐药（Dark Agouti）大鼠的品系中的转录基因表达。
3. Involvement of cocaine-amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats. [J] . Filippetti R, Kloting I, Massi M, Peptides: An International Journal . 2007,第10期

机译：可卡因-苯丙胺调节的转录物参与黑暗刺豚鼠和Wistar Ottawa Karlsburg W大鼠对伤害感受肽/孤啡肽FQ的不同摄食反应。
4. Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system [O] . Serena Battistoni, Ingrid Kloting, Carlo Cifani, 2011

机译：易感（WOKW）和抗药性（Dark Agouti）大鼠新陈代谢综合征的菌株中痛觉敏/孤儿菊素FQ诱导的食物摄入的性别差异：可卡因和苯丙胺调节的转录系统可能参与
5. Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system [O] . Battistoni, Serena, Kloting, Ingrid, Cifani, Carlo, 2010

机译：易感（WOKW）和抗药性（Dark Agouti）的大鼠对新陈代谢综合症的毒蕈碱/孤儿菊素FQ诱导食物摄入的性别差异：可卡因和苯丙胺调节的转录系统可能参与

Gender differences in Nociceptin/ Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system.

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